Hamzah Muhammad Zein


A reperfusion injury, also known as an ischemic reperfusion injury or a reoxygenation injury, is tissue damage caused when blood flow returns to the tissues, after a period of ischemia or oxygen deprivation (anoxia or hypoxia). One of the most common reperfusion injuries is the heart. When blood flow to the coronary circulation is compromised, myocardial ischemia and eventually cell death occur. When reperfused, it accelerates the necrotic process of myocytes, which undergo irreversible, cell swelling. In addition, the electrophysiological changes of the heart, thus manifesting arrhythmias

Full Text:



Araszkiewicz, Aleksander, et al. The impact of ischemia-reperfusion injury on the effectiveness of primary angioplasty in ST-segment elevation myocardial infarction. Postępy w Kardiologii Interwencyjnej= Advances in Interventional Cardiology, 2013, 9.3: 275.

Gross, Garrett J.; auchampach, John A. Reperfusion injury: does it exist?. Journal of molecular and cellular cardiology, 2007, 42.1: 12-18.

Zarbock, Alexander, et al. Ischemia-reperfusion injury and anesthesia. BioMed research international, 2014, 2014.

Kalogeris T, Baines CP, Krenz M, Korthuis RJ. Cell biology of ischemia/reperfusion injury. InInternational review of cell and molecular biology 2012 Jan 1 (Vol. 298, pp. 229-317). Academic Press.

Guyton A, Hall J. Textbook of Medical Physiology. Philadelphia: WB Saunders; 2010.

Fröhlich GM, Meier P, White SK, Yellon DM, Hausenloy DJ. Myocardial reperfusion injury: looking beyond primary PCI. European heart journal. 2013 Mar 27;34(23):1714-22.

Garcia-Dorado D, Oliveras J. Myocardial oedema: a preventable cause of reperfusion injury?. Cardiovascular research. 1993 Sep;27(9):1555-63.

Galimov ER. The role of p66shc in oxidative stress and apoptosis. Acta Naturae (англоязычная версия). 2010;2(4 (7)).

Flaherty JT. Myocardial injury mediated by oxygen free radicals. The American journal of medicine. 1991 Sep 30;91(3):S79-85.

Lejay A, Meyer A, Schlagowski AI, Charles AL, Singh F, Bouitbir J, Pottecher J, Chakfé N, Zoll J, Geny B. Mitochondria: mitochondrial participation in ischemia–reperfusion injury in skeletal muscle. The international journal of biochemistry & cell biology. 2014 May 1;50:101-5.

Ardan T, Kovačeva J, Čejková J. Comparative histochemical and immunohistochemical study on xanthine oxidoreductase/xanthine oxidase in mammalian corneal epithelium. Acta histochemica. 2004 Feb 26;106(1):69-75.

de Vries DK, Kortekaas KA, Tsikas D, Wijermars LG, van Noorden CJ, Suchy MT, Cobbaert CM, Klautz RJ, Schaapherder AF, Lindeman JH. Oxidative damage in clinical ischemia/reperfusion injury: a reappraisal. Antioxidants & redox signaling. 2013 Aug 20;19(6):535-45.

Amirudin, R., Nella, S. 2004. Peran Radikal Bebas Pada penyakit Hati Kronis, Diagnosticum.Bandung, Prodia Diagnosticum Educational Service

Suprapto B, 2006, Biological Antioxidant : What are They ?. Kumpulan Makalah Lengkap PIT VII Endokrinologi, Surakarta : UNS Press, hal : 25-29

Hardiman D, 2006, Antioxidant in Diabetic Complication and Insulin Resistance. Kumpulan Makalah Lengkap PIT VII Endokrinologi, Surakarta : UNS Press, Hal : 43-51

Betteridge DJ, 2000, What is Oxidative Stress ? . Metabolisme, 49, No 2 Supll, page : 3-8

Mayes PA, 1997, Struktur dan fungsi Vitamin Larut Lemak. Biokimia Harper. Ed 24, jakarta, Penerbit Buku Kedokteran EGC, pp : 633-43

Eltzschig HK, Collard CD. Vascular ischaemia and reperfusion injury. British medical bulletin. 2004 Jan 1;70(1):71-86.

Darwin M. The pathophysiology of ischemic injury. Biopreservation Inc. 1995;2008.

Kusuoka H, Porterfield , Weleman H. Pathophysiology and pathogenesis of stunned myocardium. J.Clin.Invest. 1987; 79: 950-961.

Kim SJ, Kudej RK, Yatani A, Kim YK, Takagi G, Honda R, et al. A novel mechanism for myocardial stunning involving impaired Ca2+ handling. Circ Res. 2001; 89: 831-37.

Halestrap AP, Pasdois P. The role of the mitochondrial permeability transition pore in heart disease. Biochimica et Biophysica Acta (BBA)-Bioenergetics. 2009 Nov 1;1787(11):1402-15.

Münzel T, Camici GG, Maack C, Bonetti NR, Fuster V, Kovacic JC. Impact of oxidative stress on the heart and vasculature: part 2 of a 3-part series. Journal of the American College of Cardiology. 2017 Jul 11;70(2):212-29.

Piper HM, Meuter K, Schäfer C. Cellular mechanisms of ischemia-reperfusion injury. The Annals of thoracic surgery. 2003 Feb 1;75(2):S644-8.

Dr John Abrams, Dr William G. Telford & Louise Rollins. Cell Death: Discriminating between apoptosis, necrosis and autophagy. Winter. 2014

Ruiz-Meana M, García-Dorado D. Pathophysiology of ischemia-reperfusion injury: new therapeutic options for acute myocardial infarction. Revista Espanola de Cardiologia.2009 Feb 1;62(02):199-209.

Braunwald E, Kloner RA. Myocardial reperfusion: a double-edged sword?. The Journal of clinical investigation. 1985 Nov 1;76(5):1713-9.

Zipes DP, Libby P, Bonow RO, Mann DL, Tomaselli GF. Braunwald's Heart Disease E-Book: A Textbook of Cardiovascular Medicine. Elsevier Health Sciences; 2018 Jan 9.

Hausenloy DJ, Yellon DM. Myocardial ischemia-reperfusion injury: a neglected therapeutic target. The Journal of clinical investigation. 2013 Jan 2;123(1):92-100.

Monassier JP. Reperfusion injury in acute myocardial infarction. From bench to cath lab. Part I: Basic considerations. Archives of cardiovascular diseases. 2008 Jul 1;101(7-8):491-500.

Fleming SD, Monestier M, Tsokos GC. Accelerated ischemia/reperfusion-induced injury in autoimmunity-prone mice. The Journal of Immunology. 2004 Sep 15;173(6):4230-5.

Abela CB, Homer-Vanniasinkham S. Clinical implications of ischaemia-reperfusion injury. Pathophysiology. 2003 Sep 1;9(4):229-40.



  • There are currently no refbacks.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

Published by Universitas Fort De Kock, Bukittinggi, Indonesia

© Human Care Journal  e-ISSN : 2528-665X P-ISSN : 2685-5798

View Human Care Journal Stats