FAKTOR-FAKTOR YANG MEMPENGARUHI SUBTIPE GEJALA MOTORIK PENYAKIT PARKINSON
Abstract
Background: Parkinson's disease (PD) is a chronic neurodegenerative disease that manifests as movement disorders. Based on motor symptoms, PD is classified into subtypes of tremor and postural instability gait disorders (PIGD). The motor symptoms subtype is a predictor of disease progression, therapeutic response, and quality of life for Parkinson's patients. The purpose of this study is to identify some factors that influence motor symptoms in Parkinson's disease.Methods: This research use cross sectional design. Samples were selected by consecutive sampling method that met the inclusion and exclusion criteria. Research subjects were 58 people. Statistical analysis using SPSS. p values <0.05 were considered statistically significant.Results: This research include 58 patients, 55.2% were men with range of age 63.5 ± 8.5 years old. The mean age at onset was 57.9 ± 9.5 years and duration of disease 6.1 ± 4.6 years. Motor symptoms 53.4% dominant tremor. There was a significant relationship between disease stage and motor symptom subtypes (p <0.001). There is no relationship between the patient's age, age at onset and duration of the disease with motor symptom subtypes.Conclusions: There is a relationship between disease stage and motor symptom. The patient's age, age at onset and duration of the disease are not related to the motor symptoms of Parkinson's patients.
Keywords
Full Text:
PDFReferences
Zigmond MJ, Robert B. Pathophysiology Of Parkinson’s Disease dalam Neuropsycho-pharmacology:the 5 th Generation Of Progress. Philadelphia: Lippincott/Williams & Wilkins. 2002: 1781-1789.
Fahn S, Jankovic, J. Parkinsonisme: Clinical feature and differential diagnosis dalam Principles and practice of movement disorders. Philadelphia: Churchill Livingstone /Elsevier.2007:79-95
Poewe W, Tanner C, Halliday G, Brundin P, Volkmann J, Schrag A, Lang A. Parkinson disease. Nature Reviews Disease Primers. 2017(3): 17013.
Kelompok Studi Gangguan Gerak PERDOSSI. Buku panduan tatalaksana penyakit Parkinson dan gangguan gerak lainnya. Jakarta. 2015:7-18
Sutia D. Hubungan kadar Alfa Sinuklein plasma dengan penyakit Parkinson. Bagian Neurologi FK UNAND. 2014: 68
Jankovic J, McDermott M, Carter J, Gauthier S, Goetz C, Golbe L, et al. Variable expression of Parkinson's disease: A base-line analysis of the DATATOP cohort. Neurology. 1990.40(10): 1529-1529.
Auyeung M, Tsoi T, Mok V, Cheung C, Lee C, Li R, Yeung E. Ten year survival and outcomes in a prospective cohort of new onset Chinese Parkinson's disease patients. Journal of Neurology, Neurosurgery & Psychiatry. 2012. 83(6): 607-611.
Jellinger K. Neuropathology of Parkinson’s Diseases. Inflammation in Parkinson's Disease. 2014: 25-74.
Thenganatt M, Jankovic J. Parkinson Disease Subtypes. JAMA Neurology. 2014.71(4):499.
Stebbins G, Goetz C, Burn D, Jankovic J, Khoo T, Tilley B. How to identify tremor dominant and postural instability/gait difficulty groups with the Movement Disorder Society Unified Parkinson's Disease Rating Scale: Comparison with the Unified Parkinson's Disease Rating Scale. Movement Disorders. 2013.28(5):668-670.
Yao Z, Shao Y, Han X. Freezing of gait is associated with cognitive impairment in patients with Parkinson disease. Neuroscience Letters. 2017(656): 126-130.
Hely, MA, Morris JG, Rail D. The Sydney Multicentre Study of Parkinson’s disease: a report on the first 3 years. J Neurol Neurosurg Psychiatry. 1989(3):324–8.
Kim S, Allen N, Canning C, Fung V. Postural Instability in Patients with Parkinson’s Disease. CNS Drugs. 2012. 27(2): 97-112.
Healy DG, Falchi M, O’Sullivan SS. Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson’s disease: a case-control study. Lancet Neurol. 2008(7):583-590.
Tanner CM, Ross GW, Jewell SA. Occupation and risk of parkinsonism: a multicenter case-control study. Arch Neurol. 2009(66):1106-1113
DOI: http://dx.doi.org/10.32883/hcj.v5i1.649
Refbacks
- There are currently no refbacks.
This work is licensed under a Creative Commons Attribution 4.0 International License.
HUMAN CARE JOURNAL
Published by Universitas Fort De Kock, Bukittinggi, Indonesia
© Human Care Journal e-ISSN : 2528-665X P-ISSN : 2685-5798